Using R to Simulate Permutation Distributions for Some Elementary Experimental Designs

Using R to Simulate Permutation Distributions for Some Elementary Experimental Designs

Null distributions of permutation tests for two-sample, paired, and block designs are simulated using the R statistical programming language. For each design and type of data, permutation tests are compared with standard normal-theory and nonparametric tests. These examples (often using real data) provide for classroom discussion use of metrics that are appropriate for the data. Simple programs...

Asymptotic probability distributions of some permutation statistics

We present in this work results on some distributions of permutation statistics of random elements of the wreath product Gr,n = Cr ! Sn. We consider the distribution of the descent number, the flag major index, the excedance, and the number of fixed points, over the whole group Gr,n or over the subclasses of derangements and involutions. We compute the mean, variance and moment generating funct...

FluxSimulator: An R Package to Simulate Isotopomer Distributions in Metabolic Networks

The representation of biochemical knowledge in terms of fluxes (transformation rates) in a metabolic network is often a crucial step in the development of new drugs and efficient bioreactors. Mass spectroscopy (MS) and nuclear magnetic resonance spectroscopy (NMRS) in combination with C labeled substrates are experimental techniques resulting in data that may be used to quantify fluxes in the m...

R++: Using Rules in Object-Oriented Designs

System requirements often express some of the behavior of a domain model in the form of policies, constraints, invariants, and rules. Although an object-oriented approach helps with the design of this model, the implementation is often cluttered with details necessary to enforce the model' s policies and constraints. As a result, the code is more prone to error and is more difficult to maintain...

Inferen e for Distributions over the Permutation